Cissus quadrangularis

Cissus quadrangularis

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Primary Information, Benefits, Effects, and Important Facts

Cissus quadrangularis is a traditional medicine usually said to come from Ayurveda but appears to have a wide range of locations which have used it medicinally due to it growing in numerous locations. Its traditional usages are mostly catered around treating feminine disorders (menopause, libido, and menstrual disorders) or treating bones (increasing bone mass or accelerating fracture healing rates) which gives it the traditional name of the 'Bone Setter'; some other traditional usages are in regards to its supposed antiulcer properties, antihemhorroid properties, and pain relieving properties.It is most frequently used by athletes, and the anecdotes of cissus seem to precede much of the science on the topic. It appears to be a very effective pain killer in rodent studies, but at this moment in time only one preliminary study has been conducted in humans; while it showed promise in athletes who experienced joint pain due to exercise (by reducing overall joint symptoms by about a third) it was still a lone study. More research is needed, but it seems promising as an alterative for joint pain in athletes since most joint health supplements do not have evidence in athletes (rather, most research is in osteoarthritis persons).
Although a potential complication in athletes is that preliminary rodent evidence suggests that cissus has sedative and muscle relaxing properties at high doses (active within 30 minutes of ingestion), suggesting that it might not make the best pre-workout supplement.
In regards to bone health, there are limited human reports of increased fracture healing rate which are poor quality of evidence due to not disclosing adequate methodlogy (ie. how they did the study) and not disclosing the source of the compound. Animal studies do show a great deal of promise in promoting bone growth, but this traditional claim also needs to be assessed in greater detail.
Finally, there are two human studies which suggest that cissus can be used as a fat loss agent but they have problems with their structure. In particular both studies are confounded with possible financial biases and since the supplements were consumed before meals with water (and cissus is known to have gum forming properties) while food intake was not measured making it wholly possible the observed effects could be due to reduced food intake, which is what happens when a gum (glucomannan, for example) is taken before a meal with water.
Overall, cissus has a good deal of promise in regards to joint and bone health in regards to athletic adults and menopausal women alike but requires a great deal more evidence to fully evaulate this promise.

10 Amazing Benefits of Cissus Quadrangularis

Some of the most important health benefits of Cissus Quadrangularis include its ability to reduce inflammation, boost bone strength, improve respiratory conditions, strengthen the immune system, soothe pain, ease menstrual issues, protect your teeth, prevent diabetes, optimizing cardiovascular function, and help with weight loss issues.
Table of Contents

What is Cissus Quadrangularis?

Closely related to common grapes, Cissus quadrangularis is a perennial plant with a number of common names, including Devil’s Backbone and Veldt Grape. Although it isn’t completely certain where Cissues quadrangularis first arose, India or Sri Lanka are two high contenders. However, this perennial plant is now found throughout Africa and Asia and is even exported to the United States due to its beneficial health qualities. Cissus quadrangularis has also been used in Ayurvedic treatments for generations. The extracts of the plant have proven to be very useful in herbal medicine, and can now be accessed in supplement form in many parts of the world. The active ingredients in Cissus quadrangularis that make it so powerful include a range of carotenoids, triterpenoids, vitamins, and minerals.
The initial popularity of the plant almost solely focused on its role in potential weight loss, but as more research was done, it was clear that the unique chemical composition of this seemingly unremarkable plant could benefit many other aspects of human health.

Health Benefits of Cissus Quadrangularis

To fully understand why this plant is so highly sought after, let’s take a more detailed look at the many health benefits of Cissus quadrangularis.

Weight Loss

The most valuable and commonly quoted benefit of Cissus quadrangularis is its significant and proven impact on weight loss. For people combining dietary changes and exercise to promote healthy weight loss, adding Cissus quadrangularis can further boost those efforts by helping to suppress the appetite and stimulating the metabolism to burn weight calories faster and use nutrients more efficiently. In dozens of studies over the past decade, Cissus quadrangularis consistently displays fat-burning powers, making it a hot new item in the weight loss markets everywhere.

Heart Health

In conjunction with the benefits above, Cissus quadrangularis has also been directly linked to lower cholesterol levels, possibly due to its strong impact on metabolic factors in the body. By reducing “bad” cholesterol in the body, Cissus quadrangularis can help to protect your cardiovascular system from an excess strain, atherosclerosis, heart, attacks, strokes, and elevated blood pressure.

Strong Bones

Cissus quadrangularis actually affects bone health in a very important way. This surprisingly powerful can help to prevent the degradation of bone matter in the body and stimulate bone growth. To be more specific, research has revealed that Cissus quadrangularis stimulates the production of osteoblasts, which are the cells in the body responsible for growing bone. This plant is also commonly suggested as an herbal remedy for people who have recently broken bones as a way to speed the healing process.

Reduced Inflammation

The general anti-inflammatory properties of certain organic compounds found in Cissus quadrangularis can help reduce swelling and irritation throughout the body, but the most conclusive studies have focused on its role in treating or lessening the symptoms of hemorrhoids. This painful condition is a difficult one to solve, but there is a definite correlation between Cissus quadrangularis supplements and reduced inflammation in that sensitive area.

Respiratory Disorders

The effects of Cissus quadrangularis are sometimes akin to steroids for your system, and when it comes to the respiratory system and conditions like asthma, supplementation with Cissus quadrangularis can prevent attacks or lessen their severity.

Diabetes Prevention

One of the unique benefits of Cissus quadrangularis is its ability to lower blood sugar levels in the body. This is done by regulating the release of blood sugar from the nutritional intake and ensuring that glucose and insulin levels remain optimal in the blood. The plant’s role in weight loss also helps in this case, as obesity is closely linked to Type II diabetes.


The high levels of ascorbic acid found in Cissus quadrangularis mean that your body gets an extra defensive shield against pathogens and foreign substances in the body, as well as additional antioxidant protection. Ascorbic acid, more commonly known as vitamin C, stimulates the production of white blood cells to fight infections and illness, thereby improving your overall health.

Wound Healing

Vitamin C is also a crucial component of collagen, the material used by the body to build everything from muscle tissue to blood vessels and arteries. High levels of vitamin C help in growth and repair, meaning that wound healing can be sped up and recovery from injury and illness can be quicker.

Dental Care

In a similar way, as Cissuc quadrangularis can help your bones, it can also help your teeth. Studies have shown a correlation between great oral health and Cissus quadrangularis supplementation.

Relief from Menstruation Cramps

One of the most common side effects of a woman’s menstrual period is cramping and bloating, as well as mood swings and hormonal imbalances. Cissus quadrangularis is able to relieve cramping and discomfort during menstruation, making it highly desirable in the market of herbal remedy world.
A Final Word of Warning: Cissus quadrangularis does not have any commonly reported allergenic effects, but some people do experience mild headaches, nausea, or flatulence, particularly when they are first exposed to the plant. As with any herbal remedy, there are potential complications with medication individuals may already be taking, so always consult your medical professional before changing your herbal supplement regimen.

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